Environmental triggers of dermatomyositis: a narrative review
| Autor: | Christina E. Bax, Lisa Pappas-Taffer, Adarsh Ravishankar, Victoria P. Werth, Spandana Maddukuri |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
030203 arthritis & rheumatology
Autoimmune disease Hepatitis Exacerbation biology business.industry Parvovirus General Medicine Dermatomyositis biology.organism_classification medicine.disease Virus Vaccination Pathogenesis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Immunology Medicine Review Article on Rheumatologic Skin Disease business |
| Zdroj: | Ann Transl Med |
| ISSN: | 2305-5839 |
| Popis: | Dermatomyositis (DM) is an autoimmune disease that affects the skin, lungs, and muscle. Although the pathogenesis of DM is not completely understood, several environmental triggers have been linked to DM onset or flare. This article specifically examines the effects of herbal supplements, drugs, infections, ultraviolet (UV) radiation, and environmental pollutants on the onset or exacerbation of DM. Herbal supplements such as Spirulina platensis, Aphanizomenon flos-aquae, Chlorella, Echinacea, and Alfalfa have been implicated and are frequently used in health foods. Medications such as hydroxyurea, TNF-α inhibitors, immune checkpoint inhibitors (ICI), and penicillamine, as well as certain viral infections, such as parvovirus B19, coxsackie virus, polyomavirus, Epstein-Barr virus (EBV), hepatitis, influenza, and human immunodeficiency viruses (HIV) have been associated with DM onset. Bacterial infections and vaccinations have also been linked to the development of DM. Additional environmental factors, including UV radiation and air pollutants, such as silica, biological/mineral dust, and particulate air matter from vehicle and industrial emissions, may also play a role in DM pathogenesis. Overall, there is general agreement that an autoimmune attack of the skin, muscle, and lungs in DM can be triggered by various environmental factors and warrants further investigation. |
| Databáze: | OpenAIRE |
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