2-Aminomethyl piperidines as novel urotensin-II receptor antagonists

Autor:	Mcmillan Lynette Jane, David J. Behm, Jian Jin, Kalindi Vaidya, Zining Wu, Michael J. Neeb, Dongchuan Shi, Karl F. Erhard, Feng Wang, Brian F. Guida, Sarah K. Lawrence, Christopher P. Evans, Stephen A. Douglas, Yonghui Wang, Ralph A. Rivero, Jyoti Disa
Rok vydání:	2008
Předmět:	medicine.drug_class Stereochemistry Clinical Biochemistry Pharmaceutical Science Carboxamide Urotensin-II receptor Biochemistry Chemical synthesis Receptors G-Protein-Coupled Methylamines Structure-Activity Relationship Piperidines Drug Discovery medicine Humans Vasoconstrictor Agents Receptor Molecular Biology Binding Sites Bicyclic molecule Chemistry Organic Chemistry Antagonist Stereoisomerism Models Chemical Molecular Medicine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 18:2860-2864
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2008.03.078
Popis:	A series of 2-aminomethyl piperidines has been discovered as novel urotensin-II receptor antagonists. The synthesis, initial structure-activity relationships, and optimization of the initial hit that resulted in the identification of potent, cross-species active, and functional urotensin-II receptor antagonists such as 1a and 11a are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93b7e819e4a3037dabc6f377d61bfb1 https://doi.org/10.1016/j.bmcl.2008.03.078 Zobrazit plný text záznamu Full Text from ScienceDirect