Does lobar or size-reduced lung transplantation offer satisfactory early and late outcomes?
| Autor: | João Santos Silva, Pierre-Emmanuel Falcoz, Gilbert Massard, Anne Olland |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Time Factors Thoracic medicine.medical_treatment 030204 cardiovascular system & hematology Global Health 03 medical and health sciences 0302 clinical medicine Humans Medicine Lung transplantation Donor pool Survival rate Evidence-Based Medicine business.industry Incidence Tissue Donors Surgery Treatment Outcome 030228 respiratory system Cardiothoracic surgery Primary Graft Dysfunction Cardiology and Cardiovascular Medicine business Follow-Up Studies Lung Transplantation |
| Zdroj: | Interact Cardiovasc Thorac Surg |
| ISSN: | 1569-9285 |
| Popis: | Summary A best evidence topic was constructed according to a structured protocol. The question addressed was whether size-reduced or lobar lung transplantation (LLTx) offers the same benefit as classic lung transplantation (LTx). Of the 147 papers found using the reported search, 9 were selected to provide the best evidence. Details of the studies regarding authors, date, journal, country of publication, study type, group studied, relevant outcomes and results are given. All studies reported survival rates of LLTx and most compared it with classical LTx. No statistical differences were reported in medium term and long term. Two of the studies reported a higher incidence of postoperative complications, such as the need for cardiopulmonary bypass, reperfusion oedema or primary graft dysfunction, and longer intubation or intensive care unit stay times. Although the largest study showed a significantly worse 1-year survival in LLTx, a sub-analysis considering patients successfully discharged showed similar outcomes at 1, 3 and 5 years when compared with classic LTx patients. We conclude that LLTx is a valid therapeutic option for recipients with significant donor size mismatch, offering similar outcomes as classical LTx in the medium term and long term. |
| Databáze: | OpenAIRE |
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