New strategies for the prevention of radiation injury: possible implications for countering radiation hazards of long-term space travel
| Autor: | Venita Miner, Ckatherine Farrell, Michael Stewart, Jason Deen, CM Chang, Edward Hilyard, William E. Jackson, James Pendergrass, Alexandra C. Miller, Mark H. Whitnall, Thomas M. Seed, Venkataraman Srinivasan, Thomas B. Elliott, Vijay K. Singh, Raymond Toles, Cyndi Inal, Sree Kumar, Michael R. Landauer, James Benjack, Dimitry M. Danilenko, Martin Gehlhaus, Vilmar Villa |
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Pathology medicine.medical_specialty Time Factors Health Toxicology and Mutagenesis medicine.medical_treatment Mice Inbred Strains Radiation-Protective Agents Bioinformatics Mice Nutraceutical medicine Animals Radiology Nuclear Medicine and imaging Neoplastic transformation Radiation Injuries Radiation injury Preventive healthcare Radiation business.industry Radiation-protective agents Amifostine Space Flight Reduced susceptibility Cytokine Preventive Medicine business medicine.drug |
| Zdroj: | Scopus-Elsevier |
| Popis: | New strategies for the prevention of radiation injuries are currently being explored with the ultimate aim of developing globally radioprotective, nontoxic pharmacologics. The prophylactic treatments under review encompass such diverse pharmacologic classes as novel immunomodulators, nutritional antioxidants, and cytokines. An immunomodulator that shows promise is 5-androstenediol (AED), a well-tolerated, long-acting androstene steroid with broad-spectrum radioprotective attributes that include not only protection against acute tissue injury, but also reduced susceptibility to infectious agents, as well as reduced rates of neoplastic transformation. Other potentially useful radioprotectants currently under study include the nutraceutical vitamin E and analogs, a chemically-engineered cytokine, interleukin-1beta, and a sustained-release formulation of an aminothiol, amifostine. Results suggest that a new paradigm is evolving for the prophylaxes of radiation injuries, based on use of newly identified, nontoxic, broad-spectrum prophylactic agents whose protective action may be leveraged by subsequent postexposure use of cytokines with organ-specific reparative functions. |
| Databáze: | OpenAIRE |
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