Characterization of mouse parvovirus infection by in situ hybridization
| Autor: | Abigail L. Smith, Lisa J. Ball-Goodrich, M D McKisic, Eric A. Johnson, Robert O. Jacoby |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Lymphoid Tissue
viruses Immunology Spleen In situ hybridization Microbiology Parvoviridae Virus Parvoviridae Infections Mice Immune system Intestinal mucosa Virology Intestine Small medicine Animals In Situ Hybridization Mice Inbred BALB C biology Parvovirus Parvovirus infection biology.organism_classification medicine.disease Molecular biology medicine.anatomical_structure Lymphatic system Liver Insect Science DNA Viral Research Article |
| Zdroj: | Journal of Virology. 69:3915-3919 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | Infection of young adult BALB/cByJ mice with mouse parvovirus-1, a newly recognized, lymphocytotropic, nonpathogenic parvovirus, was examined by in situ hybridization. Virus appeared to enter through the small intestine and was disseminated to the liver and lymphoid tissues. Strand-specific probes detected virion DNA in a consistently larger number of cells than replicative forms of viral DNA and/or viral mRNA. The number of signal-positive cells in the intestinal mucosa, lymph nodes, spleen, and thymus increased through day 10 after oral inoculation but decreased after seroconversion. Positive cells were still detected, however, in peripheral lymphoid tissues of mice examined at 9 weeks postinoculation. The results underscore the need to assess potential effects of persistent mouse parvovirus-1 infection on immune function in mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|