PVA and PCL nanofibers are suitable for tissue covering and regeneration
| Autor: | A Nečasová, Karolina Vocetkova, R Divín, Evžen Amler, V Sovková, Alois Nečas, J Fedačko, Jiří Beneš, M Beneš, J. Uhlík, M. Kralovic, A Kestlerová, J Beznoska, J Holešovský |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Physiology Swine Polyesters Nanofibers 030204 cardiovascular system & hematology Polyvinyl alcohol 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Biopsy medicine Animals Smart skin Wound Healing integumentary system medicine.diagnostic_test Regeneration (biology) Nanofiber scaffold General Medicine Grafting Bandages chemistry Nanofiber Polyvinyl Alcohol Swine Miniature Wound healing 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | Physiological research. 68(Suppl 4) |
| ISSN: | 1802-9973 |
| Popis: | The aim of the study was to evaluate the safety and efficacy of a new therapeutic approach to skin defects resulting from split thickness grafting. Within the study, nanofiber-based dressings fabricated using polyvinyl alcohol (PVA) and poly-ε-caprolactone (PCL) were used, with different mass density. The study was performed in 1 female minipig. Nine defects (approx. 4x4 cm) were made in the superficial skin layer. The tested materials were applied to the squared skin defect and covered by a Jelonet paraffin gauze, sutured in the corners of the defects. The animal was monitored daily during the healing process (21 days). On day 5, 12, and 27, the healing of the wound was evaluated, and a biopsy was performed for further histologic testing. At the end of the study (on day 27 after the procedure), the animal was euthanized, and a standard pathologic evaluation was performed. We can conclude that the nanofiber scaffold which was well tolerated, could be used as a smart skin cover which could be functionalized with another bioactive substances directly on the surgeon table, among potential bioactive substances belong platelet derivatives, antibiotics, etc. |
| Databáze: | OpenAIRE |
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