Outpatient 5-fluorouracil, folinic acid and cisplatin in patients with advanced esophageal carcinoma
| Autor: | Jorgen L. Jensen, Angela Hrincu, Ian A. Kerr, Rakesh Goel, Georg A. Bjarnason, Anthony Fields, C. Cripps, Kong E. Khoo, Ellen Warner |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Esophageal Neoplasms medicine.medical_treatment Leucovorin Neutropenia Adenocarcinoma Gastroenterology Severity of Illness Index Drug Administration Schedule Folinic acid Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Esophagus Aged Aged 80 and over Ontario Chemotherapy Esophageal disease business.industry Liver Neoplasms Hematology General Medicine Middle Aged medicine.disease Surgery medicine.anatomical_structure Treatment Outcome Oncology Fluorouracil Carcinoma Squamous Cell Disease Progression Female Cisplatin business medicine.drug |
| Zdroj: | Acta oncologica (Stockholm, Sweden). 38(2) |
| ISSN: | 0284-186X |
| Popis: | In a multicenter phase II study, 30 patients with unresectable, locally advanced or metastatic squamous cell or adenocarcinoma of the esophagus were treated with folinic acid 200 mg/m2/d, 5-FU 300 mg/m2/d, and cisplatin 20 mg/m2/d intravenously for 5 days every 4 weeks. Two of 13 patients with squamous cell carcinoma (SCC) had a complete response (CR), but one died of pneumonia after 9 months while still in CR, and the other still in CR after more than 5 years. Six other patients (3 SCC, 2 of 16 with adenocarcinoma, 1 mixed histology) had a partial response with a median duration of 9 months (range 5 to 57 + months) for an overall response rate of 27%. A further 6 patients (20%) had stable disease. Grade 4 neutropenia occurred in 6 patients (20%), with 5 requiring antibiotics for associated fever. Other grade 4 toxicities were nausea and vomiting (1), anemia (1), and thrombocytopenia (1); there were three early deaths (emphysema, cardiac arrest, pulmonary embolism). This combination appears to be an active, convenient regimen for advanced esophageal cancer, resulting in prolonged remission and survival in some patients. |
| Databáze: | OpenAIRE |
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