Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer
| Autor: | Konstantin Maslov, Lihong V. Wang, Arie Krumholz, Haixin Ke, Catherine M. Appleton, Julie A. Margenthaler, Alejandro Garcia-Uribe, Todd N. Erpelding |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty Pathology Sentinel lymph node Breast Neoplasms 02 engineering and technology 01 natural sciences Article 010309 optics Breast cancer 0103 physical sciences Medicine Humans Lymph node Cancer staging Neoplasm Staging Multidisciplinary business.industry Sentinel Lymph Node Biopsy Axillary Lymph Node Dissection 021001 nanoscience & nanotechnology medicine.disease Primary tumor 3. Good health Axilla medicine.anatomical_structure Lymphatic Metastasis Female Radiology Lymph Ultrasonography Mammary 0210 nano-technology business |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | The detection of regional lymph node metastases is important in cancer staging as it guides the prognosis of the patient and the strategy for treatment. Sentinel lymph node biopsy (SLNB) is an accurate, less invasive alternative to axillary lymph node dissection. The sentinel lymph node hypothesis states that the pathological status of the axilla can be accurately predicted by determining the status of the first lymph nodes that drain from the primary tumor. Physicians use radio-labeled sulfur colloid and/or methylene blue dye to identify the SLN, which is most likely to contain metastatic cancer cells. However, the surgical procedure causes morbidity and associated expenses. To overcome these limitations, we developed a dual-modality photoacoustic and ultrasonic imaging system to noninvasively detect SLNs based on the accumulation of methylene blue dye. Ultimately, we aim to guide percutaneous needle biopsies and provide a minimally invasive method for axillary staging of breast cancer. |
| Databáze: | OpenAIRE |
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