Evaluation of mutagenic activity of the organo-selenium compound Selol by use of the Salmonella typhimurium mutagenicity assay
| Autor: | Iwonna Rahden-Staroń, Piotr Suchocki, Hanna Czeczot |
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| Rok vydání: | 2010 |
| Předmět: |
Salmonella typhimurium
Salmonella Health Toxicology and Mutagenesis chemistry.chemical_element medicine.disease_cause Antioxidants Microbiology Ames test Organoselenium Compounds Genetics medicine Plant Oils Sunflower Oil Selenium Compounds Selenium Compound biology Mutagenicity Tests Chemistry food and beverages biology.organism_classification Enterobacteriaceae Molecular biology S9 fraction Toxicity Selenium Bacteria |
| Zdroj: | Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 699:44-46 |
| ISSN: | 1383-5718 |
| Popis: | We examined the mutagenic activity of the anti-oxidant Selol, an organo-selenium compound, by use of the Salmonella typhimurium mutagenicity assay (Ames test) with strains TA97a, TA98, TA100, TA 1535 and TA102 in the absence and in the presence of metabolic activation with an S9 fraction from Aroclor-induced rat liver. Doses were 330, 500, 1000 and 5000 μg per plate. Selol contains the element selenium (valency, +4) in its structure and it may have chemopreventive and anticancer activity. Selol was found to be non-toxic and non-mutagenic for test doses up to 5% per plate (which designates the declared content of Selenium (+4) as 5000 μg per plate) in all the S. typhimurium strains. |
| Databáze: | OpenAIRE |
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