Case–Case Comparison of Candida auris Versus Other Candida Species Bloodstream Infections: Results of an Outbreak Investigation in Colombia
Autor: | Matthew J. Stuckey, Brendan R Jackson, Adriana Mariño, Sandra Rivera, Nancy A. Chow, Franklin E Prieto, Gordana Derado, Carmen Varón, Shawn R. Lockhart, Diego H. Cáceres, Maria Victoria Ovalle, Jorge Díaz, Tom Chiller, Andres Espinosa-Bode, Paige A. Armstrong, Indira Berrio, Patricia Escandón, Nohora Villalobos, Soraya Salcedo |
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Rok vydání: | 2020 |
Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Antifungal Agents Veterinary (miscellaneous) 030106 microbiology Colombia Applied Microbiology and Biotechnology Microbiology Disease Outbreaks law.invention Diabetes Complications Diagnosis Differential Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Medical microbiology Risk Factors law Sepsis Internal medicine Acute care medicine Humans Blood culture Candida Retrospective Studies Cross Infection Infection Control medicine.diagnostic_test business.industry Public health Candidiasis Candidemia Outbreak Odds ratio Middle Aged bacterial infections and mycoses Intensive care unit Intensive Care Units Treatment Outcome Candida auris Female business Agronomy and Crop Science |
Zdroj: | Mycopathologia. 185:917-923 |
ISSN: | 1573-0832 0301-486X |
Popis: | Candida auris is an emerging multidrug-resistant yeast that causes outbreaks in healthcare settings around the world. In 2016, clinicians and public health officials identified patients with C. auris bloodstream infections (BSI) in Colombian healthcare facilities. To evaluate potential risk factors and outcomes for these infections, we investigated epidemiologic and clinical features of patients with C. auris and other Candida species BSI. We performed a retrospective case-case investigation in four Colombian acute care hospitals, defining a case as Candida spp. isolated from blood culture during January 2015–September 2016. C. auris BSI cases were compared to other Candida species BSI cases. Odds ratio (OR), estimated using logistic regression, was used to assess the association between risk factors and outcomes. We analyzed 90 patients with BSI, including 40 with C. auris and 50 with other Candida species. All had been admitted to the intensive care unit (ICU). No significant demographic differences existed between the two groups. The following variables were independently associated with C. auris BSI: ≥ 15 days of pre-infection ICU stay (OR: 5.62, CI: 2.04–15.5), evidence of severe sepsis (OR: 3.70, CI 1.19–11.48), and diabetes mellitus (OR 5.69, CI 1.01–31.9). Patients with C. auris BSI had longer lengths of ICU stay than those with other candidemias, suggesting that infections are acquired during hospitalization. This is different from other Candida infections, which are usually thought to result from autoinfection with host flora. |
Databáze: | OpenAIRE |
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