Biochemical genetics of macaques. III. Inheritance of carbonic anhydrase II polymorphism in rhesus monkeys
| Autor: | W. H. Stone, John L. VandeBerg, Martin Curie-Cohen, Kathy Benforado, G. N. Bittner |
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| Rok vydání: | 1982 |
| Předmět: |
Male
Erythrocytes Carbonic anhydrase II Bicarbonate Biology Biochemistry Isozyme chemistry.chemical_compound Gene Frequency Carbonic anhydrase Genetics Animals Allele Carbonic Anhydrase I Molecular Biology Alleles Crosses Genetic Ecology Evolution Behavior and Systematics Carbonic Anhydrases Polymorphism Genetic Homozygote General Medicine Macaca mulatta Molecular biology Isoenzymes Phenotype chemistry Dehydratase biology.protein Female Hemoglobin |
| Zdroj: | Biochemical Genetics. 20:437-441 |
| ISSN: | 1573-4927 0006-2928 |
| DOI: | 10.1007/bf00484694 |
| Popis: | The primary function of mammalian red-cell carbonic anhydrase (EC 4.2.1.1; carbonate dehydratase) is to catalyze the hydration of carbon dioxide released in body tissues and to catalyze the dehydration of bicarbonate ions in the lungs. Three isozymes designated CA I (or B), CA II (or C), and CA I I I are known in mammals , and each is coded by an independent gene locus (Koester et al., 1977; Holmes, 1977; Tashian et al., 1980a, b). The concentrations of the CA I and CA II isozymes are high in red blood cells (RBC) of most mammals; indeed, the concentration of carbonic anhydrase appears to be second only to that of hemoglobin in RBC (see Tashian and Carter, 1976). Polymorphism in carbonic anhydrase I I of rhesus monkeys ( M a c a c a m u l a t t a ) has been known for over a decade (Tashian, 1965; Tashian et al., 1968, 1971). The variation has been assumed to be controlled by autosomal codominant alleles. This assumption was based primarily on population data, but has been supported by limited data from pedigreed families (Tashian et al., 1971; Smith, 1980). Here we present extensive pedigree data which unequivocally demonstrate that the carbonic anhydrase I I phenotypes are |
| Databáze: | OpenAIRE |
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