Lymphocyte specificity to protein antigens. II. Fine specificity of T- cell activation with cytochrome c and derived peptides as antigenic probes
| Autor: | J M Chiller, G Corradin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1979 |
| Předmět: |
Lymphocyte
T cell T-Lymphocytes Immunology Peptide Cytochrome c Group Lymphocyte Activation Epitope Epitopes Mice Antigen Species Specificity medicine Immunology and Allergy Animals Amino Acid Sequence Horses Peptide sequence chemistry.chemical_classification biology Cytochrome c H-2 Antigens Articles Molecular biology In vitro Peptide Fragments medicine.anatomical_structure Biochemistry chemistry biology.protein Cattle Lymph Nodes Rabbits Immunologic Memory |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | Murine T-lymphocyte specificity was determined in a system of antigen driven in vitro T-cell proliferation using cytochrome c molecules from different species, their derived peptides and reconstituted hybrid proteins. It was observed that primed T cells could discriminate between peptide fragments which differed from each other at a single amino acid residue. These conclusions were substantiated by the pattern of cross-reactivity noted in the response of closely related cytochrome c proteins as well as when artificial hybrid molecules reconstituted by the covalent linkage of peptide fragments were analyzed. The pattern of specificity observed appeared to be haplotype (BDF1) dependent although similar conclusions about the fine specificity of T cells in the response to cytochrome c have been obtained in other strains but associated with different residues. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|