Low‐intensity aerobic exercise improves cardiac remodelling of adult spontaneously hypertensive rats
| Autor: | Marcelo Diarcadia Mariano Cezar, Marina Politi Okoshi, Katashi Okoshi, Bertha F. Polegato, Luana Urbano Pagan, David Rafael Abreu Reyes, Mariana Janini Gomes, Ricardo Luiz Damatto, Felipe C. Damatto, Aline R. R. Lima, Tulio M. M. Caldonazo |
|---|---|
| Přispěvatelé: | Universidade Estadual Paulista (Unesp), FAIT |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine arterial hypertension medicine.medical_specialty Short Communication Short Communications Concentric hypertrophy Blood Pressure Left Atrium Dimension 03 medical and health sciences 0302 clinical medicine Physical Conditioning Animal Rats Inbred SHR Internal medicine Animals TIMP Medicine Aerobic exercise Zymography cardiovascular diseases Rats Wistar Isovolumetric contraction Aorta Ventricular Remodeling business.industry Myocardium Heart Cell Biology Rats Intensity (physics) 030104 developmental biology 030220 oncology & carcinogenesis Hypertension cardiovascular system Cardiology Matrix Metalloproteinase 2 Molecular Medicine Hypertrophy Left Ventricular myocardial fibrosis Myocardial fibrosis metalloproteinase Analysis of variance business |
| Zdroj: | Journal of Cellular and Molecular Medicine Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1582-4934 1582-1838 |
| DOI: | 10.1111/jcmm.14530 |
| Popis: | Made available in DSpace on 2019-10-06T16:50:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Universidade Estadual Paulista We evaluated the influence of aerobic training on cardiac remodeling in untreated spontaneously hypertensive rats (SHR). Four experimental groups were used: sedentary (W-SED, n=27) and trained (WEX, n=31) normotensive Wistar rats, and sedentary (SHR-SED, n=27) and exercised (SHR-EX, n=32) hypertensive rats. At 13 months old, trained groups underwent treadmill exercise five days a week for four months. Statistical analysis: ANOVA or Kruskal-Wallis. Exercised groups had higher physical capacity. Hypertensive groups presented left ventricular (LV) concentric hypertrophy with impaired function. Left atrium diameter, LV posterior wall thickness and relative thickness, and isovolumetric relaxation time were lower in SHR-EX than SHR-SED. Interstitial collagen fraction and Type I-Type III collagen ratio were higher in SHR-SED than W-SED. In SHR-EX these parameters had intermediate values between W-EX and SHRSED with no differences between either group. Myocardial matrix metalloproteinase-2 activity, evaluated by zymography, was higher in SHR-SED than W-SED and SHR-EX. TIMP-2 was higher in hypertensive than normotensive groups. In conclusion, low intensity aerobic exercise reduces left atrium dimension and LV posterior wall thickness, and improves functional capacity, diastolic function, and metalloproteinase-2 activity in adult SHR. Botucatu Medical School UNESP Sao Paulo State University Itapeva Social and Agrarian Sciences College FAIT Botucatu Medical School UNESP Sao Paulo State University FAPESP: 2014/00747-1 FAPESP: 2015/17539-5 CNPq: 308557/2018-2 CNPq: 310876/2018-4 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text