Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm
| Autor: | Christopher J. Thorpe, Bruce Bowerman, Ann Schlesinger, J. Clayton Carter |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Mesoderm
Blastomeres Down-Regulation Spindle Apparatus Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Cell polarity medicine Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Alleles Genes Helminth 030304 developmental biology Glycoproteins Embryonic Induction 0303 health sciences Biochemistry Genetics and Molecular Biology(all) Endoderm Wnt signaling pathway High Mobility Group Proteins Cell Polarity Embryo Blastomere Helminth Proteins Spindle apparatus Cell biology DNA-Binding Proteins medicine.anatomical_structure Mutation Signal transduction 030217 neurology & neurosurgery Signal Transduction Transcription Factors |
| Zdroj: | Cell. 90(4) |
| ISSN: | 0092-8674 |
| Popis: | A polarizing signal induces endoderm production by a 4-cell stage blastomere in C. elegans called EMS. We identified 16 mutations in five genes mom-1 through mom-5 , required for EMS to produce endoderm. mom-1, mom-2 , and mom-3 are required in the signaling cell, P 2 , while mom-4 is required in EMS. P 2 signaling downregulates an HMG domain protein, POP-1, in one EMS daughter. The sequence of mom-2 predicts that it encodes a member of the Wnt family of secreted glycoproteins, which in other systems activate HMG domain proteins. Defective mitotic spindle orientations in mom mutant embryos indicate that Wnt signaling influences cytoskeletal polarity in blastomeres throughout the early embryo. |
| Databáze: | OpenAIRE |
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