Vascular endothelial growth factor receptor 2, but not S100A4 or S100A6, correlates with prolonged survival in advanced urothelial carcinoma
| Autor: | Carl-Henrik Shah, Kristina Viktorsson, Rolf Lewensohn, Lena Kanter, Anders Ullén, Robert Rosenblatt, Jurate Asmundsson, Amir Sherif |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Oncology medicine.medical_specialty Treatment response Urology VEGF receptors medicine.medical_treatment Cell Cycle Proteins Disease-Free Survival S100 Calcium Binding Protein A6 Cystectomy Internal medicine Biomarkers Tumor medicine Humans S100 Calcium-Binding Protein A4 Disease prognosis Aged Retrospective Studies Urothelial carcinoma biology business.industry S100 Proteins food and beverages Kinase insert domain receptor Middle Aged Prognosis Immunohistochemistry Survival Analysis Vascular Endothelial Growth Factor Receptor-2 Urinary Bladder Neoplasms biology.protein Female business |
| Zdroj: | Urologic Oncology: Seminars and Original Investigations. 32:1215-1224 |
| ISSN: | 1078-1439 |
| DOI: | 10.1016/j.urolonc.2014.04.015 |
| Popis: | A major challenge in muscle-invasive urothelial carcinoma (UC) is to identify biomarkers that can predict disease prognosis and treatment response after cystectomy. Therefore, we analyzed the potential prognostic value of the proteins vascular endothelial growth factor receptor 2 (VEGFR2), S100A4, and S100A6 in UC.Retrospective outcome data and tumor specimens from 83 cystectomy patients with histologically confirmed invasive UC were included. Expression levels of VEGFR2 (also called flk-1 and KDR), S100A4, and S100A6 were analyzed in primary tumor tissue by immunohistochemistry.Immunohistochemical staining and analysis of VEGFR2, S100A4, and S100A6 showed localization mainly in tumor cell cytoplasm. High VEGFR2 expression and low tumor category were independent variables associated with longer overall survival (OS) and disease-free survival, revealed by a bivariate Cox proportional hazards regression model (both P0.001). In addition, the univariate log-rank test and the Cox model demonstrated that OS beyond 2 years was significantly greater among patients with low S100A6 expression than in those with high S100A6 expression (P = 0.017 and 0.022, respectively). Differences in tumor expression of S100A4 were not significantly associated with outcome.In this study, VEGFR2 expression was significantly correlated with risk of disease relapse and OS in a defined cohort of patients with UC of the bladder treated by cystectomy. |
| Databáze: | OpenAIRE |
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