Pediatric pineoblastoma: A pooled outcome study of North American and Australian therapeutic data

Autor: Jordan R Hansford, Jie Huang, Raelene Endersby, Andrew J Dodgshun, Bryan K Li, Eugene Hwang, Sarah Leary, Amar Gajjar, Katja Von Hoff, Olivia Wells, Alison Wray, Rishi S Kotecha, David R Raleigh, Schuyler Stoller, Sabine Mueller, Steven E Schild, Pratiti Bandopadhayay, Maryam Fouladi, Eric Bouffet, Annie Huang, Arzu Onar-Thomas, Nicholas G Gottardo
Rok vydání: 2022
Předmět:
Zdroj: Neuro-oncology advances, vol 4, iss 1
Hansford, J R, Huang, J, Endersby, R, Dodgshun, A J, Li, B K, Hwang, E, Leary, S, Gajjar, A, Von Hoff, K, Wells, O, Wray, A, Kotecha, R S, Raleigh, D R, Stoller, S, Mueller, S, Schild, S E, Bandopadhayay, P, Fouladi, M, Bouffet, E, Huang, A, Onar-Thomas, A & Gottardo, N G 2022, ' Pediatric pineoblastoma : A pooled outcome study of North American and Australian therapeutic data ', Neuro-oncology advances, vol. 4, no. 1, pp. vdac056 . https://doi.org/10.1093/noajnl/vdac056
ISSN: 2632-2498
DOI: 10.1093/noajnl/vdac056
Popis: Background Pineoblastoma is a rare brain tumor usually diagnosed in children. Given its rarity, no pineoblastoma-specific trials have been conducted. Studies have included pineoblastoma accruing for other embryonal tumors over the past 30 years. These included only occasional children with pineoblastoma, making clinical features difficult to interpret and determinants of outcome difficult to ascertain. Patients and Methods Centrally or independently reviewed series with treatment and survival data from North American and Australian cases were pooled. To investigate associations between variables, Fisher’s exact tests, Wilcoxon-Mann-Whitney tests, and Spearman correlations were used. Kaplan-Meier plots, log-rank tests, and Cox proportional hazards models were used in survival analyses. Results We describe a pooled cohort of 178 pineoblastoma cases from Children’s Oncology Group (n = 82) and institutional series (n = 96) over 30 years. Children Conclusion Given the rarity of this tumor, prospective, collaborative international studies will be vital to improving the long-term survival of these patients.
Databáze: OpenAIRE
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