Linking the CHRNA5 SNP to drug abuse liability: From circuitry to cellular mechanisms
| Autor: | Julie A. Blendy, Julia K. Brynildsen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Genetic Linkage Substance-Related Disorders media_common.quotation_subject Single-nucleotide polymorphism Nerve Tissue Proteins Neuroimaging Receptors Nicotinic Polymorphism Single Nucleotide Article Nicotine 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine mental disorders medicine SNP Animals Humans media_common Pharmacology biology business.industry CHRNA5 Addiction Brain medicine.disease Substance abuse Nicotinic acetylcholine receptor 030104 developmental biology biology.protein Nerve Net business Neuroscience 030217 neurology & neurosurgery medicine.drug Addiction vulnerability |
| Zdroj: | Neuropharmacology |
| ISSN: | 1873-7064 |
| Popis: | Genetics are known to be a significant risk factor for drug abuse. In human populations, the single nucleotide polymorphism (SNP) D398N in the gene CHRNA5 has been associated with addiction to nicotine, opioids, cocaine, and alcohol. In this paper, we review findings from studies in humans, rodent models, and cell lines and provide evidence that collectively suggests that the Chrna5 SNP broadly influences the response to drugs of abuse in a manner that is not substance-specific. This finding has important implications for our understanding of the role of the cholinergic system in reward and addiction vulnerability. This article is part of the special issue on 'Vulnerabilities to Substance Abuse.' |
| Databáze: | OpenAIRE |
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