Emerging Molecular Prospective of SARS-CoV-2: Feasible Nanotechnology Based Detection and Inhibition
| Autor: | Rout George Kerry, Sushmita Patra, Swati Kumari, Jyoti Ranjan Rout, Ganesh Kumar Maurya, B. Panigrahi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
autophagy lcsh:QR1-502 Review Computational biology Biology nanobased therapeutics Microbiology lcsh:Microbiology 03 medical and health sciences Immune system inflammasome nanobased diagnosis medicine Epigenetics 030304 developmental biology 0303 health sciences 030306 microbiology Endoplasmic reticulum SARS-CoV-2 pathogenesis Autophagy COVID-19 genetics and epigenetics Inflammasome Viral replication Unfolded protein response Intracellular medicine.drug |
| Zdroj: | Frontiers in Microbiology Frontiers in Microbiology, Vol 11 (2020) |
| ISSN: | 1664-302X |
| DOI: | 10.3389/fmicb.2020.02098 |
| Popis: | The rapid dissemination of SARS-CoV-2 demonstrates how vulnerable it can make communities and is why it has attained the status of global pandemic. According to the estimation from Worldometer, the SARS-CoV-2 affected cases and deaths are exponentially increasing worldwide, marking the mortality rate as ∼3.8% with no probability of its cessation till now. Despite massive attempts and races among scientific communities in search of proper therapeutic options, the termination of this breakneck outbreak of COVID-19 has still not been made possible. Therefore, this review highlights the diverse molecular events induced by a viral infection, such as autophagy, unfolded protein response (UPR), and inflammasome, illustrating the intracellular cascades regulating viral replication inside the host cell. The SARS-CoV-2-mediated endoplasmic reticulum stress and apoptosis are also emphasized in the review. Additionally, host’s immune response associated with SARS-CoV-2 infection, as well as the genetic and epigenetic changes, have been demonstrated, which altogether impart a better understanding of its epidemiology. Considering the drawbacks of available diagnostics and medications, herein we have presented the most sensitive nano-based biosensors for the rapid detection of viral components. Moreover, conceptualizing the viral-induced molecular changes inside its target cells, nano-based antiviral systems have also been proposed in this review. |
| Databáze: | OpenAIRE |
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