Τriglycerides-glucose (TyG) index is a sensitive marker of insulin resistance in Greek children and adolescents
| Autor: | Eirini Dikaiakou, Maria Kafetzi, Elpis Vlachopapadopoulou, Fani Athanasouli, Stavroula A Paschou, Ιoannis Panagiotopoulos, Aspasia Fotinou, Stephanos Michalacos |
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| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Optimal cutoff Adolescent Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Positive correlation 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Internal medicine medicine Humans Child Triglycerides medicine.diagnostic_test Greece business.industry Curve analysis Area under the curve Mean age medicine.disease Obesity Glucose 030220 oncology & carcinogenesis Female Insulin Resistance Lipid profile business |
| Zdroj: | Endocrine. 70(1) |
| ISSN: | 1559-0100 |
| Popis: | To investigate the association between Triglyceride-glucose (TyG) index and the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Matsuda indices in Greek obese children and adolescents, in order to assess whether it could be used as a predictor of insulin resistance. 367 children (47.7% boys) with mean age of 9.9 ± 2.3 years, who were investigated for obesity, were included. After overnight fasting, TyG and HOMA-IR indices were calculated in all participants. In a subpopulation of 72 children Matsuda index was also calculated. 48.8% and 36.1% of the participants had insulin resistance according to HOMA-IR and Matsuda index respectively. TyG was significantly and positively correlated with BMI, ΗΟΜΑ-IR, lipid profile and Matsuda index. ROC curve analysis for TyG showed that the optimal cutoff value for the prediction of insulin resistance (HOMA-IR) was 7.96 with sensitivity 65% and specificity 58%. The area under the curve (AUC) was 0.65 which significantly differs from 0.5 (p |
| Databáze: | OpenAIRE |
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