Extensive Human Papillomavirus Type 7-Associated Orofacial Warts in an Immunocompetent Patient
| Autor: | Sönke Weissenborn, Herbert Pfister, Andreas Ritzkowsky, Ulrike Wieland, Thomas Krieg |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Biopsy Dermatology Papillomatosis In situ hybridization Polymerase Chain Reaction Disease Transmission Infectious medicine Humans Genetic Predisposition to Disease Human papillomavirus Papillomaviridae Gene In Situ Hybridization Immune status business.industry Transmission (medicine) Point mutation Papillomavirus Infections virus diseases General Medicine Carbon Dioxide DNA Viral Laser Therapy Viral disease Warts medicine.symptom Mouth Diseases business Immunocompetence |
| Zdroj: | Acta Dermato-Venereologica. 81:130-133 |
| ISSN: | 0001-5555 |
| Popis: | Human papillomavirus (HPV) type 7 is frequently found in butchers' warts and has been demonstrated in oral and facial warts of HIV-infected patients. The reservoirs of HPV7 and the route of transmission are still unclear. Here we describe an HIV-negative, otherwise healthy patient with extensive, recurrent orofacial papillomatosis whose immune status proved to be normal and who had no history of meat handling. HPV7 L1 gene DNA that differed in 3 point mutations from the HPV7 prototype could be detected in 2 morphologically distinct, perioral lesions by different PCR protocols. In situ hybridization confirmed the presence of HPV7 DNA in the nuclei of vacuolated cells of the granular layer. Our data show that HPV7 can lead to perioral, spiky warts and brownish plaques in immunocompetent patients who had never been working as a meat or fish handler. |
| Databáze: | OpenAIRE |
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