Minimally important differences for interpreting European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 scores in patients with head and neck cancer
| Autor: | Kim Cocks, Madeleine King, Jammbe Z. Musoro, Vincent Grégoire, Jean-Pascal Machiels, Andrew Bottomley, Galina Velikova, Sjoukje F. Oosting, Mirjam A. G. Sprangers, Christian Simon, Mogens Groenvold, Corneel Coens, Silke Tribius, Susanne Singer |
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| Přispěvatelé: | UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Unité d'oncologie médicale, Medical Psychology, APH - Mental Health, APH - Personalized Medicine, CCA - Cancer Treatment and Quality of Life, APH - Aging & Later Life |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
minimally important difference 03 medical and health sciences 0302 clinical medicine Quality of life Surveys and Questionnaires Linear regression Medicine Humans 030212 general & internal medicine Retrospective Studies Core (anatomy) business.industry REGRESSION-ANALYSIS Head and neck cancer Cancer Regression analysis EORTC QLQ-C30 medicine.disease humanities Clinical trial health-related quality of life Otorhinolaryngology Sample size determination Head and Neck Neoplasms Research Design 030220 oncology & carcinogenesis Physical therapy Quality of Life head and neck cancer sense organs business |
| Zdroj: | Head & Neck, Vol. 42, no. 11, p. 3141-3152 (2020) Head and Neck: Journal of the Sciences and Specialties of the Head and Neck, 42(11), 3141-3152. Wiley Head & neck, 42(11), 3141-3152. John Wiley and Sons Inc. |
| ISSN: | 1097-0347 1043-3074 |
| Popis: | Background We aimed to estimate minimally important difference (MID) for interpreting group-level change over time for European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scores in head and neck cancer. Methods Data were derived retrospectively from two published EORTC trials. Clinical anchors were selected using correlation strength and clinical plausibility of the given anchor/QLQ-C30 scale pair. MIDs for within-group and between-group change were estimated via the mean change method and linear regression, respectively. Distribution-based MIDs were also examined. MIDs for two of the scales, dyspnea and nausea/vomiting, are more uncertain considering their low correlations with the anchors. Results Anchor-based MIDs could be determined for deterioration in 7 of the 14 QLQ-C30 scales assessed, and in 3 scales for improvement. MIDs varied by scale, direction of change, and anchor. Absolute MID values ranged from 5 to 15 points for within-group change and 4 to 12 for between-group change. Most MIDs were within 4 to 10 points. Conclusions Our findings, if confirmed, will aid interpreting changes in selected QLQ-C30 scale scores over time and inform sample size calculations in future clinical trials in head and neck cancer. |
| Databáze: | OpenAIRE |
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