IGFBP-3 and IGFBP-10 (CYR61) up-regulation during the development of Barrett's oesophagus and associated oesophageal adenocarcinoma: potential biomarkers of disease risk

Autor: Laura J. Hardie, R J Olliver, J S Darnton, Christopher P. Wild, Olorunda Rotimi, E Di Martino
Rok vydání: 2006
Předmět:
Adult
Male
medicine.medical_specialty
Pathology
Esophageal Neoplasms
Health
Toxicology and Mutagenesis
Clinical Biochemistry
Adenocarcinoma
Biochemistry
Gastroenterology
Polymerase Chain Reaction
Insulin-like growth factor-binding protein
Immediate early protein
Immediate-Early Proteins
Barrett Esophagus
Internal medicine
medicine
Humans
RNA
Messenger
Aged
biology
Esophageal disease
Case-control study
Cancer
Middle Aged
medicine.disease
Immunohistochemistry
Epithelium
Up-Regulation
Gene Expression Regulation
Neoplastic
Insulin-Like Growth Factor Binding Proteins
medicine.anatomical_structure
Insulin-Like Growth Factor Binding Protein 3
Case-Control Studies
biology.protein
Intercellular Signaling Peptides and Proteins
Female
hormones
hormone substitutes
and hormone antagonists
Biomarkers
Cysteine-Rich Protein 61
Zdroj: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 11(6)
ISSN: 1354-750X
Popis: Dys-regulation of the insulin-like growth factor (IGF) system increases the risk of a number of malignancies. The aim of this study was to investigate the role of members of the IGF binding protein (IGFBP) superfamily in the development of oesophageal adenocarcinoma (EAC) and their possible use as markers of disease risk. Expression of IGFBP-2, IGFBP-3, IGFBP-4, and IGFBP-10/CYR61 was assessed using Real-Time-polymerase chain reaction (PCR) and immunohistochemistry in oesophageal tissues from Barrett's oesophagus (BE) patients with and without associated EAC, and in control subjects. IGFBP-3, IGFBP-4, and IGFBP-10/CYR61 mRNA levels were up-regulated in Barrett's (n=17) and tumour tissue of EAC patients (n=18) compared with normal tissue of control subjects without BE or EAC (n=18) (p
Databáze: OpenAIRE
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