Host–commensal interaction promotes health and lifespan in Caenorhabditis elegans through the activation of HLH-30/TFEB-mediated autophagy
| Autor: | Miroslav Dinić, Aleksandra Trifunovic, Jelena Đokić, Marija Herholz, Dušan Radojević, Katarina Novović, Uroš Kačarević, Nataša Golić |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
autophagy
Aging Limosilactobacillus fermentum media_common.quotation_subject Longevity Regulator HLH-30 Lipid droplet Basic Helix-Loop-Helix Transcription Factors Animals Homeostasis Caenorhabditis elegans Caenorhabditis elegans Proteins media_common biology Host (biology) Autophagy Lipid metabolism Cell Biology biology.organism_classification Lipid Metabolism Cell biology Mitochondria Lactobacillus fermentum TFEB Research Paper |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | Gut homeostasis is maintained by the close interaction between commensal intestinal microbiota and the host, affecting the most complex physiological processes, such as aging. Some commensal bacteria with the potential to promote healthy aging arise as attractive candidates for the development of pro-longevity probiotics. Here, we showed that heat-inactivated human commensal Lactobacillus fermentum BGHV110 (BGHV110) extends the lifespan of Caenorhabditis elegans and improves age-related physiological features, including locomotor function and lipid metabolism. Mechanistically, we found that BGHV110 promotes HLH-30/TFEB-dependent autophagy to delay aging, as longevity assurance was completely abolished in the mutant lacking HLH-30, a major autophagy regulator in C. elegans. Moreover, we observed that BGHV110 partially decreased the content of lipid droplets in an HLH-30-dependent manner and, at the same time, slightly increased mitochondrial activity. In summary, this study demonstrates that specific factors from commensal bacteria can be used to exploit HLH-30/TFEB-mediated autophagy in order to promote longevity and fitness of the host. |
| Databáze: | OpenAIRE |
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