Peripheral gangrene in adult‐onset Kawasaki disease
| Autor: | M Robineau, I Bonté, L Laroche, Alfred Mahr, Loïc Guillevin |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Vasculitis Systemic disease medicine.medical_specialty Fever medicine.medical_treatment Immunology Mucocutaneous Lymph Node Syndrome Diagnosis Differential Gangrene Rheumatology medicine Humans Immunology and Allergy Autoimmune disease Aspirin Vascular disease business.industry General Medicine medicine.disease Surgery Amputation Kawasaki disease business medicine.drug |
| Zdroj: | Scandinavian Journal of Rheumatology. 34:71-73 |
| ISSN: | 1502-7732 0300-9742 |
| Popis: | Kawasaki disease (KD) is an acute vasculitis characterized by marked tropism of the coronary vessels. Usually a childhood disease, KD can occasionally be observed in adults. We report a case of adult-onset KD that presented as a prolonged fever of unknown origin with subsequent development of severe vasculitis, manifested by coronary aneurysms and peripheral gangrene of the lower limbs. Therapy with intravenous immunoglobulins, corticosteroids, aspirin, anticoagulants, and prostacyclin analogue resulted in rapid improvement in the patient's condition but he required partial distal amputation for irreversible gangrene. Peripheral ischaemia leading to gangrene is a very rare feature of KD vasculitis with only 19 cases previously published in the Medline-indexed literature. The outcomes of those patients were poor, being either fatal or requiring distal amputation. All prior cases affected young children less than 1 year old and, to the best of our knowledge, the present case is the first description of peripheral gangrene in adult-onset KD. |
| Databáze: | OpenAIRE |
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