Short- and Long-term Histological Changes in Liver Parenchyma After Different Resection Methods and Their Potential Role in Treatment of Colorectal Liver Metastasis
| Autor: | András Papp, Balázs Németh, Ildikó Takács, András Palkovics, András Fincsur, István Kiss, András Vereczkei |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research Surgical margin medicine.medical_specialty Necrosis medicine.medical_treatment Thermal effect Metastasis Resection 03 medical and health sciences 0302 clinical medicine Animal model medicine Animals Humans Neoplasm Metastasis Rats Wistar business.industry Liver Neoplasms Margins of Excision Diathermy General Medicine medicine.disease Surgery Liver Oncology 030220 oncology & carcinogenesis medicine.symptom Colorectal Neoplasms business Liver parenchyma |
| Zdroj: | Anticancer Research. 40:1359-1365 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | BACKGROUND/AIM Optimal surgical margins, parenchymal-sparing technique and the effect of the surgical devices on the liver resection surface are currently hot topics. The aim of this study was to set up a surviving animal model to detect histological changes on the resection surface induced by the resection method and the thermal effect of monopolar electrocautery in 'spray mode'. MATERIALS AND METHODS Eighteen male Wistar rats were used; all rats were subjected to standardized liver resection and resection surface coagulation. Resection surface samples were collected immediately after the operation from the first group, and at 1 week and 3 weeks after the operation from the second and third groups, respectively. The samples were histologically investigated. RESULTS Spray diathermy was shown to cause parenchymaI destruction of varying depth on the resection surface due to immediate coagulation and consequent necrosis. CONCLUSION Spray diathermy on the resection surface can also destroy the area that contains possible tumor cells after R1 resection and increases the tumor clearance without worse survival outcomes. |
| Databáze: | OpenAIRE |
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