Two parenteral amino acid solutions and plasma levels of amino acids in the neonate: A randomized trial
| Autor: | Miguel Ángel Villasís-Keever, Martha Lledias-Corona, Silvia Aguilar-Monroy, Andrea Huerta-Tecanhuey, María Salomé Anaya-Florez, Mardia López-Alarcón, Jorge Maldonado-Hernández, Irene Montalvo-Velarde, Lourdes Barbosa-Cortés, Olivia Madrigal-Muñiz, Héctor Jaime González-Cabello |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Taurine Parenteral Nutrition Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Gestational Age Breast milk Umbilical cord Gastroenterology Umbilical Cord 03 medical and health sciences chemistry.chemical_compound Electrolytes 0302 clinical medicine Methionine Cholestasis Double-Blind Method Internal medicine medicine Birth Weight Humans Cysteine Amino Acids chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics Milk Human business.industry Incidence Infant Newborn Gestational age medicine.disease Amino acid Solutions medicine.anatomical_structure Parenteral nutrition Glucose chemistry Female business |
| Zdroj: | Nutrition (Burbank, Los Angeles County, Calif.). 65 |
| ISSN: | 1873-1244 |
| Popis: | Objective In neonates on total parenteral nutrition (TPN), amino acids may be a risk factor for developing total parenteral nutrition–associated cholestasis (TPNAC). We aimed, first, to compare methionine, cysteine, and taurine plasma levels between neonates on TPN who were receiving an intravenous amino acid solution based on a breast milk aminogram and those on an intravenous solution of pediatric amino acids based on an umbilical cord aminogram, and second, to determine the frequency of TPNAC. Methods A double-blind randomized controlled trial was conducted. Ninety-four neonates with a birthweight of 1000g or more and a gestational age of 30 wk or older were admitted and enrolled. Blood samples were obtained at 0, 7, and 14 d of TPN, and plasma amino acid concentrations were determined by ultra-high-resolution liquid chromatography. Continuous variables were compared using the Wilcoxon rank-sum test or Student's t test; categorical variables were compared using the Fisher exact test. Results Thirty-five neonates completed the study (Primene, n = 14; TrophAmine, n = 21). On day 14, methionine plasma concentrations were significantly lower in the Primene group than in the TrophAmine group (27 µmol/L versus 32.9 µmol/L, P = 0.044); the taurine concentration was significantly higher in the same group (72.4 µmol/L versus 45.3 µmol/L, P Conclusions Administering an intravenous solution of pediatric amino acids based on the umbilical cord aminogram yielded a higher taurine and lower methionine plasma concentration than did administering a similar solution based on the breast milk aminogram. |
| Databáze: | OpenAIRE |
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