Induced production of halogenated diphenyl ethers from the marine-derived fungus Penicillium chrysogenum
| Autor: | Keumja Yun, Viviane N. Nenkep, Hong Dae Choi, Jung Sook Kang, Byeng Wha Son, Guohua Yang |
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| Rok vydání: | 2010 |
| Předmět: |
Magnetic Resonance Spectroscopy
Molecular Conformation Bioengineering Ether Fungus Penicillium chrysogenum Biochemistry chemistry.chemical_compound Polybrominated diphenyl ethers Halogens Halogenated Diphenyl Ethers Organic chemistry Molecular Biology biology Phenyl Ethers General Chemistry General Medicine Nuclear magnetic resonance spectroscopy Free Radical Scavengers biology.organism_classification Ascorbic acid chemistry Molecular Medicine Fermentation |
| Zdroj: | Chemistrybiodiversity. 7(11) |
| ISSN: | 1612-1880 |
| Popis: | Manipulation of the fermentation of the marine-derived fungus Penicillium chrysogenum by addition of CaBr(2) resulted in induced production of bromodiphenyl ether analogs. Two new free-radical-scavenging polybrominated diphenyl ethers, 1 and 2, and three known diphenyl ethers, 3,3'-dihydroxy-5,5'-dimethyldiphenyl ether (3), and an inseparable mixture of violacerol-I (4) and violacerol-II (5) were isolated. The structures of the two new polybromodiphenyl ethers 1 and 2 were assigned by combined spectroscopic-data analysis, including deuterium-induced isotope effect. Compounds 1-3, and a mixture of 4 and 5 exhibited radical-scavenging activities against 1,1-diphenyl-2-picrylhydrazyl with IC(50) values of 18, 15, 42, and 6 μM, respectively. With the exception of 3, the compounds were, therefore, more active than the positive control, ascorbic acid (IC(50) 20 μM). |
| Databáze: | OpenAIRE |
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