Unusually Severe Cases of Kingella kingae Osteoarticular Infections in Children
| Autor: | Cindy Mallet, Estelle Litzelmann, Victor Dubois-Ferriere, Keyvan Mazda, Mathie Lorrot, Brice Ilharreborde, Stéphane Bonacorsi, Dimitri Ceroni |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
musculoskeletal diseases Microbiology (medical) Pediatrics medicine.medical_specialty Neisseriaceae Infections Treatment outcome Kingella kingae Infectious Epidemiology Kingella kingae/isolation & purification medicine Humans Retrospective Studies ddc:618 biology business.industry Infant Bone Diseases Infectious Neisseriaceae Infections/diagnosis/epidemiology/microbiology/therapy biology.organism_classification Bone Diseases Infectious/diagnosis/epidemiology/microbiology/therapy Anti-Bacterial Agents The primary diagnosis Anti-Bacterial Agents/therapeutic use Treatment Outcome Infectious Diseases Child Preschool Pediatrics Perinatology and Child Health Female business |
| Zdroj: | Pediatric Infectious Disease Journal, Vol. 33, No 1 (2014) pp. 1-4 |
| ISSN: | 0891-3668 |
| DOI: | 10.1097/inf.0b013e3182a22cc6 |
| Popis: | With the development of molecular biology and specific polymerase chain reaction, Kingella kingae has become the primary diagnosis of osteoarticular infections in young children. Clinical features of these osteoarticular infections are typically mild, and outcome is almost always favorable. We report a series of unusually severe cases of K. kingae osteoarticular infections.All patients with severe osteoarticular infections at presentation were reviewed retrospectively in 2 European pediatric centers. K. kingae was identified using real-time polymerase chain reaction in blood, fluid joint or osseous samples. Clinical, laboratory tests and radiographic data during hospitalization and follow-up were analyzed.Ten children (mean age 21 ± 12 months) with severe osteoarticular infections caused by K. kingae were identified between 2008 and 2011. Diagnostic delay averaged 13.2 ± 8 days. Only 1 patient was febrile at admission, and 50% children had normal C-reactive protein values (≤10 mg/dL) at presentation. Surgical treatment was performed in all cases. Intravenous antibiotic therapy by cephalosporins for an average of 8 ± 6 days was followed by oral treatment for 27 ± 6 days. Mean follow-up was 24.8 ± 9 months, and satisfactory outcomes were reported in all cases. Two patients (20%) developed a central epiphysiodesis of the proximal humerus during follow-up, but without significant clinical consequence for the moment.Because of their mild clinical features at onset, diagnosis of K. kingae osteoarticular infections can be delayed. Care should be taken for early detection and treatment of these infections because bony lytic lesions and potentially definitive growth cartilage damage can occur. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|