MicroRNAs 1915-3p, 2861, and 4532 Are Associated with Long-Term Renal Function Decline in Type 1 Diabetes
| Autor: | Tatiana S. Pelaes, Maria Lúcia Corrêa-Giannella, Vishal S. Vaidya, Daniele Pereira Santos-Bezerra, Maria Beatriz Monteiro |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Urinary system Clinical Biochemistry Renal function Disease 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus medicine Outpatient clinic Humans Diabetic Nephropathies Letter to the Editor Type 1 diabetes Biochemistry (medical) medicine.disease MicroRNAs 030104 developmental biology Diabetes Mellitus Type 1 Cohort Kidney Failure Chronic Microalbuminuria Female Glomerular Filtration Rate |
| Zdroj: | Clin Chem |
| ISSN: | 1530-8561 |
| Popis: | To the Editor: Diabetic kidney disease (DKD)1 is the leading cause of end-stage renal disease worldwide (1). Microalbuminuria is the earliest indicator of DKD in diabetes mellitus (DM). Microalbuminuria is clinically sensitive but not specific to this disease, which in some patients progresses with rapid glomerular filtration rate (GFR) decline (2). Research on new urinary biomarkers had demonstrated the ability of microRNAs (miRNAs) to discriminate between individuals with DKD and either healthy or non-DKD individuals (3). In an article published in Clinical Chemistry , Cardenas-Gonzalez et al. identified miRNAs miR-1915-3p, miR-2861, and miR-4532 as novel urinary miRNA biomarkers in DKD (3). Despite validating the results in different DM cohorts, the study's cross-sectional design was unable to address causality or prediction of subsequent outcomes. To further evaluate the prognostic potential of these new biomarkers, we tested the correlation between the expression of the 3 miRNAs and long-term estimated GFR (eGFR) decline in a cohort of 113 individuals with type 1 diabetes (T1D) who were recruited from 2013 to 2017 at the Diabetes Outpatient Clinic, Hospital das Clinicas. At the time of recruitment, spot urine samples were collected in sterile RNase-free flasks, centrifuged for 10 min, 3000 g at 4 °C, and frozen at −80 °C without additives or protease inhibitors within 4 h from collection. Clinical and demographic data [sex, age, T1D duration, use of angiotensin-converting … |
| Databáze: | OpenAIRE |
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