Cellular origins of dsRNA, their recognition and consequences
| Autor: | Y Grace Chen, Sun Hur |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Mammals
Innate immune system viruses fungi RNA Cell Biology Biology Nervous System Malformations Virus Replication Genome Immunity Innate Article Cell biology Pathogenesis RNA silencing Immune system Autoimmune Diseases of the Nervous System Viral replication Virus Diseases Animals Receptor Molecular Biology RNA Double-Stranded |
| Zdroj: | Nat Rev Mol Cell Biol |
| ISSN: | 1471-0080 |
| Popis: | Double-stranded RNA (dsRNA) is associated with most viral infections - it either constitutes the viral genome (in the case of dsRNA viruses) or is generated in host cells during viral replication. Hence, nearly all organisms have the capability of recognizing dsRNA and mounting a response, the primary aim of which is to mitigate the potential infection. In vertebrates, a set of innate immune receptors for dsRNA induce a multitude of cell-intrinsic and cell-extrinsic immune responses upon dsRNA recognition. Notably, recent studies showed that vertebrate cells can accumulate self-derived dsRNAs or dsRNA-like species upon dysregulation of several cellular processes, activating the very same immune pathways as in infected cells. On the one hand, such aberrant immune activation in the absence of infection can lead to pathogenesis of immune disorders, such as Aicardi-Goutieres syndrome. On the other hand, the same innate immune reaction can be induced in a controlled setting for a therapeutic benefit, as occurs in immunotherapies. In this Review, we describe mechanisms by which immunostimulatory dsRNAs are generated in mammalian cells, either by viruses or by the host cells, and how cells respond to them, with the focus on recent developments regarding the role of cellular dsRNAs in immune modulation. |
| Databáze: | OpenAIRE |
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