Comparing speech characteristics in spinocerebellar ataxias type 3 and type 6 with Friedreich ataxia

Autor: Matthis Synofzik, Ludger Schöls, Tobias Lindig, Bettina Brendel, Theresa Schölderle, Hermann Ackermann, Wolfram Ziegler
Rok vydání: 2014
Předmět:
Adult
Male
congenital
hereditary
and neonatal diseases and abnormalities
medicine.medical_specialty
Neurology
Ataxia
physiopathology [Speech Disorders]
Speech characteristics
physiopathology [Spinocerebellar Ataxias]
physiopathology [Friedreich Ataxia]
Intelligibility (communication)
Audiology
Severity of Illness Index
Speech Disorders
Dysarthria
physiopathology [Machado-Joseph Disease]
Severity of illness
Motor speech disorders
otorhinolaryngologic diseases
medicine
Humans
Spinocerebellar Ataxias
ddc:610
etiology [Spinocerebellar Ataxias]
Aged
physiopathology [Dysarthria]
etiology [Dysarthria]
Machado-Joseph Disease
Middle Aged
medicine.disease
complications [Friedreich Ataxia]
nervous system diseases
etiology [Speech Disorders]
Friedreich Ataxia
complications [Machado-Joseph Disease]
Spinocerebellar ataxia
Female
Neurology (clinical)
medicine.symptom
Psychology
Zdroj: Journal of neurology 262(1), 21-26 (2014). doi:10.1007/s00415-014-7511-8
ISSN: 1432-1459
DOI: 10.1007/s00415-014-7511-8
Popis: Patterns of dysarthria in spinocerebellar ataxias (SCAs) and their discriminative features still remain elusive. Here we aimed to compare dysarthria profiles of patients with (SCA3 and SCA6 vs. Friedreich ataxia (FRDA), focussing on three particularly vulnerable speech parameters (speaking rate, prosodic modulation, and intelligibility) in ataxic dysarthria as well as on a specific oral non-speech variable of ataxic impairment, i.e., the irregularity of oral motor diadochokinesis (DDK). 30 Patients with SCA3, SCA6, and FRDA, matched for group size (n = 10 each), disease severity, and disease duration produced various speech samples and DDK tasks. A discriminant analysis was used to differentiate speech and non-speech parameters between groups. Regularity of DDK was specifically impaired in SCA3, whereas impairments of speech parameters, i.e., rate and modulation were stronger affected in SCA6. Speech parameters are particularly vulnerable in SCA6, while non-speech oral motor features are notably impaired in SCA3.
Databáze: OpenAIRE
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