Non-canonical role for Lpar1-EGFP subplate neurons in early postnatal mouse somatosensory cortex
| Autor: | Anna Hoerder-Suabedissen, Yasushi Nakagawa, Andre Marques-Smith, Filippo Ghezzi, Zoltán Molnár, Alexandra Rowett, Simon J. B. Butt, Daniel Lyngholm, Gokul Parameswaran, Paul G. Anastasiades, Cristiana Vagnoni |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Mouse Somatosensory system neural development Mice 0302 clinical medicine Thalamus Cortex (anatomy) Subplate neocortex Receptors Lysophosphatidic Acid Biology (General) neural circuits Neurons education.field_of_study Neocortex General Neuroscience General Medicine medicine.anatomical_structure Medicine Neural development Research Article GABA Agents QH301-705.5 Science Population Green Fluorescent Proteins Optogenetics Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences medicine Biological neural network Animals education optogenetics General Immunology and Microbiology Somatosensory Cortex Axons Electric Stimulation laser scanning photostimulation 030104 developmental biology Animals Newborn Vibrissae subplate Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | eLife, Vol 10 (2021) Ghezzi, F, Marques-Smith, A, Anastasiades, P G, Lyngholm, D, Vagnoni, C, Rowett, A, Parameswaran, G, Hoerder-Suabedissen, A, Nakagawa, Y, Molnar, Z & Butt, S J B 2021, ' Non-canonical role for Lpar1-EGFP subplate neurons in early postnatal mouse somatosensory cortex ', eLife, vol. 10, e60810 . https://doi.org/10.7554/eLife.60810 eLife |
| Popis: | Subplate neurons (SPNs) are thought to play a role in nascent sensory processing in neocortex. To better understand how heterogeneity within this population relates to emergent function, we investigated the synaptic connectivity of Lpar1-EGFP SPNs through the first postnatal week in whisker somatosensory cortex (S1BF). These SPNs comprise of two morphological subtypes: fusiform SPNs with local axons and pyramidal SPNs with axons that extend through the marginal zone. The former receive translaminar synaptic input up until the emergence of the whisker barrels, a timepoint coincident with significant cell death. In contrast, pyramidal SPNs receive local input from the subplate at early ages but then – during the later time window – acquire input from overlying cortex. Combined electrical and optogenetic activation of thalamic afferents identified that Lpar1-EGFP SPNs receive sparse thalamic innervation. These data reveal components of the postnatal network that interpret sparse thalamic input to direct the emergent columnar structure of S1BF. |
| Databáze: | OpenAIRE |
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