Decreased fibronectin expression in Met/HGF-mediated tumorigenesis
| Autor: | Gregory A. Taylor, Kiyotoshi Sekiguchi, Miriam R. Anver, Mike Jeffers, Craig P. Webb, George F. Vande Woude, Han Mo Koo |
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| Rok vydání: | 1998 |
| Předmět: |
Cancer Research
Mice Nude medicine.disease_cause Receptor tyrosine kinase Mice Transforming Growth Factor beta Gene expression Tumor Cells Cultured Genetics medicine Animals Humans RNA Messenger Molecular Biology Cell Line Transformed Differential display biology Hepatocyte Growth Factor Neoplasms Experimental Proto-Oncogene Proteins c-met Molecular biology Fibronectins Gene Expression Regulation Neoplastic Fibronectin Cell Transformation Neoplastic Cell culture Tumor progression biology.protein Hepatocyte growth factor Carcinogenesis medicine.drug |
| Zdroj: | Oncogene. 17:1179-1183 |
| ISSN: | 1476-5594 0950-9232 |
| DOI: | 10.1038/sj.onc.1202004 |
| Popis: | The tyrosine kinase receptor Met and its ligand, hepatocyte growth factor (HGF)/scatter factor are involved in the etiology and progression of a number of human cancers. Coexpression of Met and HGF in mesenchymal cells increases the tumorigenic and metastatic potential of the cells. In the studies described here, we used differential display screening to identify changes in gene expression that are initiated by Met/HGF, and that may lead to these phenotypes. We learned that Met/HGF signaling resulted in greatly decreased fibronectin mRNA production in three different human and mouse tumor cell lines; these decreases in fibronectin mRNA were paralleled by decreases in fibronectin protein. We also found a progressive decrease in fibronectin in tumor explants and metastases derived from the Met/HGF transformed cells. The absence of fibronectin expression is a frequent cancer phenotype; our results indicate that decreases in fibronectin correlate with, but are not essential for, MetHGF/SF-mediated tumorigenesis. |
| Databáze: | OpenAIRE |
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