Synthesis of licochalcone analogues with increased anti-inflammatory activity
| Autor: | Jin-Kyung Kim, Jong-Gab Jun, Cheol Gi Kim, So-Ra Yun, Si-Jun Kim |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Cell Survival
Stereochemistry medicine.drug_class Clinical Biochemistry Pharmaceutical Science Nitric Oxide Ring (chemistry) Biochemistry Anti-inflammatory Nitric oxide chemistry.chemical_compound Chalcones Drug Discovery medicine Animals Mast Cells Cytotoxicity Molecular Biology Cell Proliferation Dose-Response Relationship Drug Molecular Structure Chemistry Anti-Inflammatory Agents Non-Steroidal Organic Chemistry Rats Molecular Medicine |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 24:181-185 |
| ISSN: | 0960-894X |
| Popis: | Licohalcones have been reported to have various biological activities. However, most of licochalcones also showed cytotoxicity even though their versitile utilities. Licochalcones B and D, which have common substituents at aromatic ring B, are targeted to modify the structure at aromatic ring A for inflammatory studies. Licochalcone derivatives ( 1 – 6 ) thus prepared are compared for their suppression ability of nitric oxide (NO) production and showed 9.94, 4.72, 10.1, 4.85, 2.37 and 4.95 μM of IC 50 values, respectively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect