Modified effect of active or passive smoking on the association between age and abdominal aortic calcification: a nationally representative cross-sectional study
| Autor: | Luyan Lv, Xiongli Yue, Yungui Yang, Shixian Wu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Passive smoking Cross-sectional study medicine.medical_treatment Population Logistic regression medicine.disease_cause Risk Factors Internal medicine medicine Humans cardiovascular imaging Aorta Abdominal education Subclinical infection education.field_of_study business.industry Smoking Infant vascular medicine General Medicine Arteriosclerosis Atherosclerosis medicine.disease Cross-Sectional Studies Ageing cardiology Smoking cessation Medicine Tobacco Smoke Pollution Public Health business |
| Zdroj: | BMJ Open, Vol 11, Iss 10 (2021) BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | ObjectiveThe deleterious effects of smoking on atherosclerosis were well known; however, the interaction among ageing, smoking and atherosclerosis remains unclear. This study tested the hypothesis that the association between age and vascular calcification, a critical mark of atherosclerosis, was modified by smoking.DesignCross-sectional study.SettingA nationally representative sample, the National Health and Nutrition Examination Surveys 2013–2014.ParticipantsThis study included 3140 adults aged 40–80 years with eligible data for abdominal aortic calcification (AAC). Active and passive smoking exposure was identified through self-reports and tobacco metabolites (serum cotinine and urinary 4-methylnitrosamino-3-pyridyl-1-butanol).Primary outcome measuresAAC score was determined using dual-energy X-ray absorptiometry (DXA) scans. OR was estimated using the logistic regression method to assess the association between age and the presence of severe or subclinical AAC stratified by smoking exposure. The survey-weighted Wald test was used to evaluate potential interactions.ResultsAAC was positively associated with age in the general population. After adjustment for age, sex, race/ethnicity and other cardiovascular risk factors, age was significantly associated with the odds of severe AAC (OR for each 5-year increase in age: 1.66, 95% CI 1.48 to 1.87, pConclusionsSmoking significantly accelerated the progression of age-related subclinical atherosclerosis. Early smoking cessation should be encouraged among young smokers. The effect of passive smoking exposure on arteriosclerosis should be assessed further. |
| Databáze: | OpenAIRE |
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