Antiemetic activity of the NK1 receptor antagonist GR205171 in the treatment of established postoperative nausea and vomiting after major gynaecological surgery
| Autor: | L E Cheli-Muller, B A McQuade, J Lees, B Bryssine, P Schoeffler, C F Spraggs, P Diemunsch |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Antiemetic Agent Adolescent medicine.drug_class Nausea Tetrazoles Anesthesia General Placebo Gynecologic Surgical Procedures Double-Blind Method Neurokinin-1 Receptor Antagonists Piperidines medicine Antiemetic Humans General anaesthesia Aged business.industry Middle Aged Anesthesiology and Pain Medicine Anesthesia Postoperative Nausea and Vomiting Vomiting Antiemetics NK1 receptor antagonist Female medicine.symptom business Postoperative nausea and vomiting |
| Zdroj: | British journal of anaesthesia. 82(2) |
| ISSN: | 0007-0912 |
| Popis: | In this double-blind, randomized, parallel group study, we have investigated the antiemetic activity of the potent and selective NK1 receptor antagonist GR205171 25 mg i.v. compared with placebo in the treatment of established postoperative nausea and vomiting (PONV) in patients after major gynaecological surgery performed under general anaesthesia. The incidence of PONV in the study population was 65%. Thirty-six patients were treated with placebo or GR205171 (18 patients per group). GR205171 produced greater control of PONV than placebo over the 24-h assessment period. The stimuli for emesis after PONV are multifactorial and the efficacy of GR205171 in this study supports the broad spectrum potential for NK1 receptor antagonists in the management of postoperative emesis. GR205171 was well tolerated and no adverse events were reported that would preclude the further development of this agent. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|