Functional Dyspepsia and Chronic Idiopathic Gastric Stasis
| Autor: | Maria Teresa Granata, Antonio Morelli, Gabrio Bassotti, Renato Palumbo, M Gaburri, Ferruccio Farroni, F Narducci |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
Gastrointestinal tract Gastric emptying business.industry digestive oral and skin physiology medicine.disease Naloxone Hydrochloride Gastroenterology digestive system diseases medicine.anatomical_structure Dyskinesia Internal medicine Naloxone Internal Medicine medicine Duodenum Gastroparesis Opiate medicine.symptom business medicine.drug |
| Zdroj: | Archives of Internal Medicine. 146:716 |
| ISSN: | 0003-9926 |
| DOI: | 10.1001/archinte.1986.00360160140019 |
| Popis: | Chronic idiopathic gastric stasis can be responsible for unexplained dyspepsia. Because exogenous opiates inhibit gastric emptying and endogenouslike substances are present in the gastrointestinal tract, we tested the hypothesis that increased endogenous opiate activity may be responsible for chronic idiopathic gastric stasis. Eighteen patients with chronic idiopathic gastric stasis and ten healthy volunteers were studied by gastrointestinal manometry. Scintigraphic technique also was used, during which either intravenous saline or naloxone hydrochloride were infused. Manometry showed gastric hypomotility in ten patients and duodenal hyperdyskinesia in the remaining eight patients. Naloxone did not alter gastric emptying in healthy subjects or corrected gastric stasis in patients with gastric hypomotility, while it normalized gastric emptying in patients with duodenal dyskinesia. It seems that either gastroparesis or duodenal dyskinesia can promote gastric stasis and chronic dyspepsia, and endogenous opiates participate in the pathogenesis of gastric stasis in patients with duodenal dyskinesia. |
| Databáze: | OpenAIRE |
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