The potential for clinical translation of antibody-targeted nanoparticles in the treatment of acute myeloid leukaemia
| Autor: | Jianfeng Guo, Mary R. Cahill, Caitriona M. O'Driscoll, Sharon L. McKenna, Yao Sun, Limei Wang, Zhongcheng Cong, Xue Luan |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Immunoconjugates Pharmaceutical Science Antineoplastic Agents Malignancy Translational Research Biomedical 03 medical and health sciences Drug Delivery Systems Targeted nanoparticles hemic and lymphatic diseases medicine Animals Humans neoplasms Drug Carriers biology business.industry Antibodies Monoclonal Treatment options Translation (biology) medicine.disease Leukemia Myeloid Acute Haematopoiesis 030104 developmental biology biology.protein Cancer research Nanoparticles Antibody Myeloid leukaemia business |
| Zdroj: | Journal of Controlled Release. 286:154-166 |
| ISSN: | 0168-3659 |
| DOI: | 10.1016/j.jconrel.2018.07.024 |
| Popis: | Acute myeloid leukaemia (AML) is a heterogeneous haematopoietic malignancy. Currently, treatment options offer a 5 year survival of60%. In elderly patients, where the incidence is highest, the survival is much lower. Current standard treatments have significant toxicity and are least well tolerated in older adults, where the need is greatest. Therefore, alternatives are required. Monoclonal antibodies (mAbs), due to the specific targeting to cell surface proteins (i.e. antigens), represent a promising strategy for drug delivery to malignant cells. This concept favours the therapeutic ratio simultaneously by reducing toxicity and increasing efficacy. Although delivery of chemotherapeutics, genes and imaging agents using multifunctional nanoparticles has been substantially explored in treating solid cancers, less information on this approach is available in the case of AML. This review describes the development of antibody-targeted nanoparticulate drug delivery systems, and discusses the barriers to clinical translation in the treatment of AML. |
| Databáze: | OpenAIRE |
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