Focal optogenetic suppression in macaque area MT biases direction discrimination and decision confidence, but only transiently

Autor: Gregory D. Horwitz, Danique Jeurissen, Naomi N. Odean, Yasmine El-Shamayleh, Christopher R. Fetsch, Michael N. Shadlen
Rok vydání: 2018
Předmět:
0301 basic medicine
Psychology
Pathological
Male
Brain activity and meditation
QH301-705.5
Science
Decision Making
Motion Perception
Stimulus (physiology)
Optogenetics
Macaque
Choice Behavior
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
biology.animal
Rhesus macaque
Microstimulation
Animals
Visual Pathways
Motion perception
Neural networks (Neurobiology)
Biology (General)
Neurons
Brain Mapping
General Immunology and Microbiology
biology
Behavior
Animal
General Neuroscience
FOS: Clinical medicine
Neurosciences
Cognition
General Medicine
biology.organism_classification
Macaca mulatta
Temporal Lobe
030104 developmental biology
plasticity
Visual Perception
Medicine
Neuroscience
030217 neurology & neurosurgery
Photic Stimulation
Research Article
Zdroj: eLife
eLife, Vol 7 (2018)
ISSN: 2050-084X
Popis: Insights from causal manipulations of brain activity depend on targeting the spatial and temporal scales most relevant for behavior. Using a sensitive perceptual decision task in monkeys, we examined the effects of rapid, reversible inactivation on a spatial scale previously achieved only with electrical microstimulation. Inactivating groups of similarly tuned neurons in area MT produced systematic effects on choice and confidence. Behavioral effects were attenuated over the course of each session, suggesting compensatory adjustments in the downstream readout of MT over tens of minutes. Compensation also occurred on a sub-second time scale: behavior was largely unaffected when the visual stimulus (and concurrent suppression) lasted longer than 350 ms. These trends were similar for choice and confidence, consistent with the idea of a common mechanism underlying both measures. The findings demonstrate the utility of hyperpolarizing opsins for linking neural population activity at fine spatial and temporal scales to cognitive functions in primates.
Databáze: OpenAIRE
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