Effects of scalp block with bupivacaine versus levobupivacaine on haemodynamic response to head pinning and comparative efficacies in postoperative analgesia: A randomized controlled trial
| Autor: | Banu O Can, Hülya Bilgin |
|---|---|
| Přispěvatelé: | Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Anabilim Dalı., Bilgin, Hülya, A-7338-2016 |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_treatment Procedures Biochemistry law.invention Postoperative pain 0302 clinical medicine 030202 anesthesiology Anesthesia Ropivacaine Peroperative complication Prospective Studies Anesthetics Local Drug safety Propofol Aged 80 and over Analogs and derivatives Pain Postoperative Clinical outcome Innervation Skull block General Medicine Double blind procedure Comparative effectiveness Clinical trial Levobupivacaine Randomized controlled trial Craniotomy Human medicine.medical_specialty Diclofenac Analgesic Major clinical study levobupivacaine Article 03 medical and health sciences Humans Aged Scalp Pharmacology & pharmacy Scalp block Very elderly Brain tumor Nerve block Surgery Comparative study 030217 neurology & neurosurgery Haemodynamic response Anaesthesia law Heart Rate Tachycardia Visual analog scale Pain Measurement local anaesthesia Nerve Block Middle Aged Mean arterial pressure Fracture Fixation Intramedullary Fentanyl medicine.anatomical_structure Hypertension Female Rocuronium Pethidine medicine.drug Adult Phase 4 clinical trial Adolescent Midazolam Sodium chloride Research & experimental medicine Pain Pathophysiology Remifentanil Double-Blind Method Postoperative analgesia medicine Arterial Pressure Medicine research & experimental Prospective study Placebo Brain artery aneurysm Bupivacaine Local anesthetic agent Drug effects haemodynamics business.industry Biochemistry (medical) Infiltration Brain arteriovenous malformation bupivacaine Hemodynamics Research Reports Cell Biology Drug efficacy Neurosurgery Postoperative Nausea and Vomiting Intramedullary nailing business Controlled study |
| Zdroj: | The Journal of International Medical Research |
| ISSN: | 1473-2300 0300-0605 |
| Popis: | Objective This study was performed to determine the effects of scalp blocks with bupivacaine versus levobupivacaine on the haemodynamic response during craniotomy and the efficacies and analgesic requirements of these drugs postoperatively. Methods This randomized, prospective, placebo-controlled, double-blind study included 90 patients (age, 18–85 years; American Society of Anesthesiologists physical status, I or II). The patients were randomly divided into three groups: those who received 20 mL of 0.5% bupivacaine (Group B, n = 30), 20 mL of 0.5% levobupivacaine (Group L, n = 30), or saline as a placebo (Group C, n = 30). Scalp blocks were performed 5 min before head pinning. The primary outcome was the mean arterial pressure (MAP), and the secondary outcomes were the heart rate (HR), visual analogue scale (VAS) scores, and additional intraoperative and postoperative drug use. Postoperative pain was evaluated using a 10-cm VAS. Results During head pinning and incision, the MAP and HR were significantly higher in Group C. The additional drug requirement for intraoperative hypertension and tachycardia was significantly higher in Group C. There were no significant differences in MAP, HR, or VAS scores between Groups B and L. Conclusion Both bupivacaine and levobupivacaine can be effectively and safely used for scalp blocks to control haemodynamic responses and postoperative pain. |
| Databáze: | OpenAIRE |
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