Differential impact of cocaine on meal patterns in female and male rats
| Autor: | Paul J. Wellman, Jack R. Nation, Dao H. Ho |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Period (gene) Estrous Cycle General Biochemistry Genetics and Molecular Biology Eating Norepinephrine Sex Factors Neurochemical Cocaine Dopamine Uptake Inhibitors Dopamine Internal medicine medicine Animals Rats Long-Evans General Pharmacology Toxicology and Pharmaceutics Estrous cycle Meal Dose-Response Relationship Drug business.industry Feeding Behavior General Medicine Behavioral activation Rats Dose–response relationship Endocrinology Female business Injections Intraperitoneal medicine.drug |
| Zdroj: | Life Sciences. 82:359-366 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/j.lfs.2007.11.004 |
| Popis: | Female rats, relative to males, exhibit greater behavioral activation to cocaine and other psychostimulants, but the effect of sex and the estrous cycle in modulating the hypophagic action of cocaine has not been evaluated. Meal patterns were recorded in automated food hoppers during the first 3 h of the dark phase in adult female and male rats after administration of ascending cocaine doses (0, 7.5, and 15 mg/kg cocaine, i.p.) on successive trials. Cocaine produced a greater suppression of feeding as well as a reduction in meal number over a 3 h test period in female rats during estrus, relative to that noted during diestrus. In contrast, during the 180 min test period, male rats showed minimal hypophagic responses to 7.5 or 15 mg/kg cocaine. These results extend the range of behavioral perturbations induced by cocaine that are modulated by sex and by the estrous cycle and are consistent with the notion that estradiol may modulate the neurochemical actions of cocaine. |
| Databáze: | OpenAIRE |
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