MIN 14C UBT: a combination of gastric basal transit and 14C-urea breath test for the detection of Helicobacter pylori infection in human beings
| Autor: | M.L. Cakagno, O. Degrossi, A. Mitta, José Boccio, Marcela Zubillaga, P. Oliveri, Ricardo A. Caro, C. Goldman |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Spirillaceae Urea breath test Gastroenterology Isotopes of technetium Helicobacter Infections Internal medicine medicine Humans Urea Radiology Nuclear Medicine and imaging Carbon Radioisotopes Breath test Gastrointestinal tract biology medicine.diagnostic_test Helicobacter pylori Stomach digestive oral and skin physiology Carbon Dioxide biology.organism_classification medicine.anatomical_structure Basal (medicine) Breath Tests Molecular Medicine Female |
| Zdroj: | Nuclear medicine and biology. 24(6) |
| ISSN: | 0969-8051 |
| Popis: | The purpose of this work is to demonstrate that the 14 C-urea breath test (UBT) performed at different times combined with the study of the gastric basal transit, which evaluates the intragastric displacement of a labeled solution under fasting conditions, has the advantage of being representative of the whole stomach surface and constitutes a non-aggressive test for the detection of H. pylori . This test, which has been called MIN 14 C UBT, is a modification of the conventional 14 C UBT in which low volumes of a solution of 14 C-urea together with 99m Tc-sulfur colloid are administered. The 99m Tc-sulfur colloid is not absorbed in the gastrointestinal tract and has the great advantage of allowing the "visualization" of the transit of the 14 C-urea within the gastrointestinal tract. This modification allows the simultaneous determination of the production of the 14 CO 2 and the place where this process occurs. The results show that there is a good correlation between the images obtained and the breath samples collected. We found that this test has a sensitivity of 98% and a specificity of 96% for H. pylori detection. |
| Databáze: | OpenAIRE |
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