HLA Antigen Sharing in Italian Couples in Which Women Were Affected by Gestational Trophoblastic Tumors
| Autor: | J. A. Grasso, M. Mastrone, Fabio Scarpellini, M Sbracia |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Genotype Immunology Trophoblastic Tumor Locus (genetics) Human leukocyte antigen Trophoblastic Neoplasms Biology Major histocompatibility complex Chorioepithelioma Antigen HLA Antigens Pregnancy Genetic linkage medicine Humans Immunology and Allergy Choriocarcinoma Spouses Hydatidiform Mole Invasive Obstetrics and Gynecology Hydatidiform Mole medicine.disease Italy Reproductive Medicine Uterine Neoplasms biology.protein Female Pregnancy Complications Neoplastic |
| Zdroj: | American Journal of Reproductive Immunology. 35:252-255 |
| ISSN: | 1046-7408 |
| DOI: | 10.1111/j.1600-0897.1996.tb00039.x |
| Popis: | PROBLEM : The development of gestational trophoblastic tumors (GTT), in which genetic factors are strongly involved, is a rare event. To test the possibility that gene(s) linked to the Major histocompatibility Complex (MHC) may have a role in both embryo growth and tumor development, the HLA typing was performed on patients affected by GTT and on their partners. METHOD : The study group of sixteen couples, in which the women were affected by an invasive mole or choriocarcinoma, and the control group of thirty normal fertile couples without history of spontaneous abortion or GTT were typed for class I and class II HLA antigen. RESULTS : The results showed no differences in single HLA-A and B antigen frequency between GTT couples and controls. In HLA-DR, locus an increased frequency of DR-6 antigen was observed (p |
| Databáze: | OpenAIRE |
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