Serum from postmenopausal women treated with a by-product of olive-oil extraction process stimulates osteoblastogenesis and inhibits adipogenesis in human mesenchymal stem-cells (MSC)
| Autor: | Cristina Navarro-Valverde, Antonio Casado-Díaz, J.M. Mata-Granados, María Concepción Romero-Sánchez, José Manuel Quesada-Gómez, M. V. Ruiz-Méndez, Gabriel Dorado, Isaac Túnez-Fiñana |
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| Přispěvatelé: | Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Junta de Andalucía |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Aging medicine.medical_specialty Antioxidant medicine.medical_treatment medicine.disease_cause Olive-pomace oil distillate Biochemistry 03 medical and health sciences Squalene chemistry.chemical_compound 0302 clinical medicine Endocrinology Osteogenesis Internal medicine Adipocytes Genetics medicine Humans Olive Oil Molecular Biology Cells Cultured Aged Coenzyme Q10 Adipogenesis Osteoblasts Vitamin E Mesenchymal stem cell Mesenchymal Stem Cells Cell Biology Middle Aged Lipoproteins LDL Postmenopause 030104 developmental biology chemistry 030220 oncology & carcinogenesis Dietary Supplements Osteoporosis Female Mesenchymal stem-cells Oxidative stress Lipoprotein |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 0531-5565 |
| Popis: | 40 Páginas; 3 Figuras; 3 Tablas Aging may enhance both oxidative stress and bone-marrow mesenchymal stem-cell (MSC) differentiation into adipocytes. That reduces osteoblastogenesis, thus favoring bone-mass loss and fracture, representing an important worldwide health-issue, mainly in countries with aging populations. Intake of antioxidant products may help to retain bone-mass density. Interestingly, a novel olive-pomace physical treatment to generate olive oil also yields by-products rich in functional antioxidants. Thus, diet of postmenopausal women was supplemented for two months with one of such by-products (distillate 6; D6), being rich in squalene. After treatment, serum from such women showed reduced both lipidic peroxidation and oxidized low-density lipoprotein (LDL). Besides, vitamin E and coenzyme Q10 levels increased. Furthermore, culture medium containing 10% of such serum both increased osteoblastogenesis and reduced adipogenesis in human MSC from bone marrow. Therefore, highly antioxidant by-products like D6 may represent a relevant source for development of functional products, for both prevention and treatment of degenerative pathologies associated with aging, like osteoporosis. Supported by grants AGL2013-45110-R of “Ministerio de Ciencia e Innovación” (MICINN); PI081692, PI15/01857. “Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad” (RETICEF) and “CIBER de Fragilidad y Envejecimiento Saludable” (CIBERFES), with support from “Instituto de Salud Carlos III” (ISCIII), “Ministerio de Economía y Competitividad” (MINECO) and European Union (EU); “Ayudas de Intensificación de la Investigación” and “Grupo CTS413” of “Junta de Andalucía”, Spain. |
| Databáze: | OpenAIRE |
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