Diagnostic usefulness of water-to-fat ratio and choline concentration in malignant and benign breast lesions and normal breast parenchyma: An in vivo 1H MRS study
| Autor: | Lia Bartella, Sandra B. Brennan, Elizabeth A. Morris, D. David Dershaw, Wei Huang, Nicole Ishill, Laura Liberman, Sunitha B. Thakur, Jason A. Koutcher |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Magnetic Resonance Spectroscopy Breast Neoplasms Malignancy Choline Breast Diseases Breast cancer Body Water In vivo Parenchyma medicine Humans Radiology Nuclear Medicine and imaging Breast skin and connective tissue diseases Aged Models Statistical Receiver operating characteristic business.industry Histology Middle Aged Ductal carcinoma medicine.disease Adipose Tissue ROC Curve Area Under Curve Invasive lobular carcinoma Female business Biomarkers |
| Zdroj: | Journal of Magnetic Resonance Imaging. 33:855-863 |
| ISSN: | 1053-1807 |
| Popis: | Purpose: To compare total choline concentrations ([Cho]) and water-to-fat (W/F) ratios of subtypes of malignant lesions, benign lesions, and normal breast parenchyma and determine their usefulness in breast cancer diagnosis. Reference standard was histology. Materials and Methods: In this HIPPA compliant study, proton MRS was performed on 93 patients with suspicious lesions (>1 cm) who underwent MRI-guided interventional procedures, and on 27 prospectively accrued women enrolled for screening MRI. (W/F) and [Cho] values were calculated using MRS data. Results: Among 88 MRS-evaluable histologically-confirmed lesions, 40 invasive ductal carcinoma (IDC); 10 invasive lobular carcinoma (ILC); 4 ductal carcinoma in situ (DCIS); 3 invasive mammary carcinoma (IMC); 31 benign. No significant difference observed in (W/F) between benign lesions and normal breast tissue. The area under curve (AUC) of receiver operating characteristic (ROC) curves for discriminating the malignant group from the benign group were 0.97, 0.72, and 0.99 using [Cho], (W/F) and their combination as biomarkers, respectively. (W/F) performs significantly (P < 0.0001;AUC = 0.96) better than [Cho] (AUC = 0.52) in differentiating IDC and ILC lesions. Conclusion: Although [Cho] and (W/F) are good biomarkers for differentiating malignancy, [Cho] is a better marker. Combining both can further improve diagnostic accuracy. IDC and ILC lesions have similar [Cho] levels but are discriminated using (W/F) values. J. Magn. Reson. Imaging 2011;33:855–863. © 2011 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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