Arrhythmias and sudden cardiac death in post-cardiac transplant patients
| Autor: | Eric Adler, Michael Eskander, Kurt S. Hoffmayer |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Heart disease POST-CARDIAC TRANSPLANT medicine.medical_treatment 030204 cardiovascular system & hematology Ventricular Function Left Sudden cardiac death 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans In patient cardiovascular diseases 030212 general & internal medicine Heart transplantation Ejection fraction business.industry Arrhythmias Cardiac Stroke Volume medicine.disease Defibrillators Implantable Death Sudden Cardiac Time course Ventricular fibrillation cardiovascular system Cardiology Heart Transplantation Cardiology and Cardiovascular Medicine business |
| Zdroj: | Current Opinion in Cardiology. 35:308-311 |
| ISSN: | 1531-7080 0268-4705 |
| Popis: | Purpose of review Orthotopic heart transplantation (OHT) significantly improves morbidity and mortality in patients with end-stage heart disease. Despite advances in surgical technique, immunosuppressive therapies, and patient monitoring, long-term risk of arrhythmias and sudden cardiac death (SCD) in the denervated heart remains unchanged. Recent findings SCD is responsible for approximately 10% of all posttransplant deaths with a pooled incidence rate of 1.30 per 100 person years and is strongly associated with cardiac allograft vasculopathy (CAV). Risk factors for SCD and CAV include higher donor age, younger recipient age, and reduced left ventricular ejection fraction. Little is known about the time course between CAV and SCD. Although some registry data establish ventricular fibrillation as a documented terminal rhythm, the arrhythmia may not be the mechanism of SCD. Summary In this review, we identify risk factors and general independent predictors of arrhythmia and SCD and discuss the utility of implantable cardiac defibrillators in post-cardiac transplant patients. |
| Databáze: | OpenAIRE |
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