B‐cell modulation with anti‐CD79b antibodies ameliorates experimental autoimmune encephalitis in mice

Autor: Kerstin Renner, Sophia Neumayer, Yvonne Talke, Simone Buchtler, Kathrin Schmidbauer, Falk Nimmerjahn, Anja Lux, Frederike Winter, Jan‐Nicklas Salewski, Matthias Mack
Rok vydání: 2022
Předmět:
Zdroj: European Journal of Immunology. 52:656-668
ISSN: 1521-4141
0014-2980
DOI: 10.1002/eji.202149523
Popis: B cells play a major role in the pathogenesis of many autoimmune diseases like MS, rheumatoid arthritis, or systemic lupus erythematosus. Depletion of B cells with anti-CD20 antibodies is an established therapy for MS. However, total B-cell depletion will also affect regulatory B cells that are known to suppress autoimmune responses. In our studies, we describe an alternative approach based on targeting CD79b that induces only partial B-cell depletion and achieves therapeutic effects by B-cell modulation. Prophylactic and therapeutic treatment with an antibody against CD79b and also a deglycosylated variant of this antibody, lacking effector function like antibody-dependent cellular cytotoxicity or complement activation, significantly reduced the development and progression of EAE in mice. Our data show that modulation of B cells via CD79b is equally effective as almost complete B-cell depletion with anti-CD20 antibodies and may constitute an alternative approach to treat MS.
Databáze: OpenAIRE
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