Serum profiling identifies ibrutinib as a treatment option for young adults with B-cell acute lymphoblastic leukaemia
| Autor: | Barbara-Ann Guinn, Ken I. Mills, Laurence Orchard, Stephanie Bonney, Viggo Van Tendeloo, Kim Orchard, Leah Cooksey, Matthew Coutinho, Stephanie Jordaens |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Lymphoma B-Cell medicine.medical_treatment 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Piperidines Internal medicine Precursor B-Cell Lymphoblastic Leukemia-Lymphoma medicine Bruton's tyrosine kinase Humans Young adult Chemotherapy biology business.industry Adenine Hematology Immunotherapy Middle Aged Clinical trial Transplantation chemistry 030220 oncology & carcinogenesis Ibrutinib biology.protein Female Human medicine Stem cell business 030215 immunology |
| Zdroj: | Jordaens, S, Cooksey, L, Bonney, S, Orchard, L, Coutinho, M, Van Tendeloo, V, Mills, K I, Orchard, K & Guinn, B-A 2020, ' Serum profiling identifies ibrutinib as a treatment option for young adults with B-cell acute lymphoblastic leukaemia ', British Journal of Haematology, vol. 189, no. 3, pp. 500-512 . https://doi.org/10.1111/bjh.16407 British journal of haematology |
| ISSN: | 0007-1048 |
| DOI: | 10.1111/bjh.16407 |
| Popis: | Acute lymphoblastic leukaemia (ALL) is a haematological malignancy that is characterized by the uncontrolled proliferation of immature lymphocytes. 80% of cases occur in children where ALL is well understood and treated. However it has a devastating affects on adults, where multi-agent chemotherapy is the standard of care with allogeneic stem cell transplantation for those who are eligible. New treatments are required to extend remission and prevent relapse to improve patient survival rates. We used serum profiling to compare samples from presentation adult B-ALL patients with age- and sex-matched healthy volunteer (HV) sera and identified 69 differentially recognised antigens (P |
| Databáze: | OpenAIRE |
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