| Autor: |
Zhiyin Wang, Dan Liu, Yimin Dai, Ruotian Li, Yaowu Zheng, Guangfeng Zhao, Jingmei Wang, Zhenyu Diao, Chenrui Cao, Haining Lv, Ning Gu, Hang Zhou, Hailin Ding, Jie Li, Xiangyu Zhu, Honglei Duan, Li Shen, Qun Zhang, Jing Chen, Huilian Hu, Xiaoyan Wang, Mingming Zheng, Yan Zhou, Yali Hu |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Hypertension (Dallas, Tex. : 1979). |
| ISSN: |
1524-4563 |
| Popis: |
Background: Preeclampsia is a complicated syndrome with marked heterogeneity. The biomarker-based classification for this syndrome is more constructive to the targeted prevention and treatment of preeclampsia. It has been reported that preeclamptic patients had elevated microRNA-155 (miR-155) in placentas or circulation. Here, we investigated the characteristics of patients with high placental miR-155 (pl-miR-155). Methods: Based on the 95th percentile (P95) of pl-miR-155 in controls, preeclamptic patients were divided into high miR-155 group (≥P95) and normal miR-155 group ( Results: About one-third of preeclamptic patients had high pl-miR-155 expression, which was positively correlated with circulating miR-155 levels. These patients could be clustered as 1 group, according to clinical manifestation, placental pathology, or transcriptomes by t-distributed stochastic neighbor embedding and hierarchical clustering analysis. Further, the pregnant mice with placental restricted miR-155 overexpression could simulate the changes of clinical signs, pathology, and transcriptome of placentas in patients with high pl-miR-155. AntagomiR-155 treatment relieved the preeclampsia-like phenotype and improved the placental vascular development in mice. Conclusions: There is at least 1 type of preeclampsia with upregulated miR-155 presenting more severe clinical manifestations. MiR-155 may be a potential therapeutic target in patients with high pl-miR-155. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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