Diminished ovarian reserve in recurrent pregnancy loss : a systematic review and meta-analysis
| Autor: | Stephen D. Keay, Siobhan Quenby, Emma R. Honess, Amar M. Karia, Bassel H. Al Wattar, Sarah J. Bunnewell |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Anti-Mullerian Hormone
0301 basic medicine Abortion Habitual medicine.medical_specialty endocrine system 03 medical and health sciences 0302 clinical medicine Ovulation Induction Pregnancy Recurrent miscarriage medicine Humans Ovarian Reserve Ovarian reserve 030219 obstetrics & reproductive medicine Estradiol Obstetrics business.industry Incidence (epidemiology) Obstetrics and Gynecology Odds ratio medicine.disease Antral follicle 030104 developmental biology Reproductive Medicine Case-Control Studies Meta-analysis Female Follicle Stimulating Hormone RG Luteinizing hormone business Infertility Female |
| ISSN: | 0015-0282 |
| Popis: | Objective To evaluate the association between diminished ovarian reserve (DOR) in women at risk of recurrent pregnancy loss (RPL) using ovarian reserve tests. Design Systematic review and meta-analysis. Setting University medical schools. Patient(s) Women with a history of RPL. Intervention(s) Systematic reviews of major electronic databases (MEDLINE, EMBASE, Web of Science, and Scopus) for studies that evaluated the incidence of DOR in women with RPL. Main Outcome Measure(s) Association between RPL and DOR. Result(s) In studies up to May 2019 we assessed quality using the Newcastle-Ottawa Scale and meta-analyzed data using a random-effect model. We included 15 studies (n = 3,082 women) reporting on six ovarian reserve tests: antimullerian hormone [AMH], antral follicle count, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, and FSH:LH ratio. More women with RPL seemed to have DOR compared with women who did not have RPL as measured by low AMH levels (odds ratio [OR] 2.77; 95% confidence interval [CI], 1.41–5.46) and AFC (OR 2.45; 95% CI, 1.16–5.19). Women with unexplained RPL also seemed to have a higher association with DOR compared with women whose RPL had a known etiology, as measured by low AMH levels (OR 3.23; 95% CI, 1.81–5.76). No statistically significant differences were found in the levels of any of the remaining ovarian reserve tests between those groups of women. Conclusion(s) There is an apparent association between DOR and RPL. Low AMH and AFC levels could predict higher odds for pregnancy loss, but more studies are needed to evaluate their prognostic value in the management of women with RPL. Systematic Review Registration Number Prospero CRD42018114673 |
| Databáze: | OpenAIRE |
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